2 edition of Mechanisms of action ofdietary fibre on lipid and cholesterol metabolism found in the catalog.
Mechanisms of action ofdietary fibre on lipid and cholesterol metabolism
European COST Concerted Action Scientific Workshop (October 23 and 24, 1993 Carry le Rouet - Marseille)
by Commission of the European Communities Directorate General XIII in Luxembourg
Written in English
At head of cover title: Commission of the European Communities.
|Statement||edited by Denis Lairon.|
|Series||COST 92 Action : Metabolic and physiological effects of dietary fibre in food, COST 92 Action|
|Contributions||Lairon, Denis., Commission of the European Communities. Directorate-General Information Technologies andIndustries and Telecommunications.|
|The Physical Object|
|Number of Pages||177|
Observations of the impact of dietary fiber on lipid metabolism were reported in cockerel in Fisher et al. () fed cockerel a 5% pectin-supplemented diet for a year and a half and found that these avian sequestered and excreted two times more cholesterol and three times more lipid than cockerel fed the standard diet [ 9 ]. It has been demonstrated that statins can increase intestinal sterol absorption. Augments in phytosterolemia seems related to cardiovascular disease. We examined the role of soluble fiber intake in endogenous cholesterol synthesis and in sterol absorption among subjects under highly effective lipid-lowering therapy. In an open label, randomized, parallel-design study with blinded endpoints.
Long-term treatment with g/d of psyllium for 26 weeks resulted in a reduction of serum total cholesterol by %, LDL-C by %, and the ratio of LDL-C to high-density lipoprotein cholesterol (HDL-C) by %. 7 Although the exact mechanism of action of psyllium in lowering cholesterol is not fully understood, it has been suggested that the. Disorders of lipid metabolism. Lipids are large, water-insoluble molecules that have a variety of biological functions, including storing energy and serving as components of cellular membranes and that line the small intestine absorb dietary lipids and process them into lipoprotein particles that enter the circulation via the lymphatic system for eventual uptake by the liver.
Hamilton, R. M. G., and K. K. Carroll. Plasma cholesterol levels in rabbits fed low fat, low cholesterol diets: Effect of dietary proteins carbohydrates and fibre from different sources. Atherosclerosis 47, PubMed CrossRef Google Scholar. Digestion and Absorption of Lipids Lipids are large molecules and generally are not carbohydrates and protein, lipids are broken into small components for most of our digestive enzymes are water-based, how does the body break down fat and make it available for the various functions it must perform in the human body?
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High-fiber diets (generally >25 g/day for women) are recommended because of their many associated health benefits (1, 2).In particular, evidence from randomized controlled trials, observational studies, and animal models demonstrates that dietary fiber lowers levels of total cholesterol and low density lipoprotein (LDL) cholesterol (1–5), which are common risk factors for cardiovascular Cited by: Dietary fibre and lipid metabolism.
Kritchevsky D. The influence of dietary fibre on lipid metabolism can be assessed at several levels. In animal studies it is possible to investigate the effects of fibre on serum and tissue lipid levels, on lipid absorption and excretion and, in specific instances, on experimental by: Dietary fibre from different sources is generally believed to regulate lipid metabolism via the following three routes: 1) adsorbing and binding bile salts to promote their excretion; 2) fermentation in the gut to generate short-chain fatty acids and inhibit the synthesis of cholesterol; 3) mediating enzyme activity to regulate lipid metabolism Cited by: 5.
Sources of dietary fibre can be divided into three groups according to their effect on plasma lipids in humans: (1) a cholesterol-lowering effect demonstrated repeatedly by pectin, guar gum. Further, high doses of lecithin in the diet might interfere with absorption of cholesterol, or they might alter the metabolism of triglycerides or low density lipoproteins (LDL).
Because of the possible beneficial effects of dietary lecithin, our laboratory has carried out a series of studies on the metabolism of by: 4.
Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters - Volume 94 Issue 3 - Ariëtte M. van Bennekum, David V.
Nguyen, Georg Schulthess, Helmut Hauser, Michael C. Phillips. Changes in pig plasma lipids to dietary cholesterol, source and level of dietary fibre and caecal infusion of propionate - mechanism of action of dietary fibre on lipid and cholesterol metabolism.
In Cost Metabolic and Physiological Aspects of Dietary Fibre in Food. The mechanism of action for the hypocholesterolaemic effect of SBF is less clear; the results of the present study point to a mechanism involving disruption of the enterohepatic bile acid circulation, possibly via changes in the rate of absorption of dietary lipid.
PMID: [Indexed for MEDLINE] Publication Types: Research Support, Non-U.S. Lipid digestion. Digestion is the first step to lipid metabolism, and it is the process of breaking the triglycerides down into smaller monoglyceride units with the help of lipase enzymes.
Digestion of fats begin in the mouth through chemical digestion by lingual ed cholesterol is not broken down by the lipases and stays intact until it enters the epithelium cells of small intestine. Mechanisms explaining the serum lipid modulating effect of dietary fibre of importance for cardiovascular disease.
A large number of similarities have been found in the effect of dietary fibre on glucose and lipid metabolism. Indeed in both cases, the viscosity effect of fibre is unanimously recognised. Cholesterol is also synthesized in the adrenal glands and reproductive organs. Cholesterol is kept in balance by homeostatic mechanisms: higher dietary intake leads to reduced synthesis in the body.
Dietary cholesterol is poorly absorbed; therefore, intake of cholesterol has little effect on blood cholesterol levels. According to recent studies, the soluble in relation to the insoluble fraction may shed some light on the effectiveness of dietary fiber in diabetes and its mechanisms. The first researches on soluble fiber showed a gastric emptying delay and a reduced absorption of macronutrients, resulting in lower blood glucose and postprandial insulin.
Re-evaluation of the mechanisms of dietary ﬁbre and implications for macronutrient bioaccessibility, digestion and postprandial metabolism Myriam M.-L. Grundy1, Cathrina H. Edwards1,2, Alan R. Mackie2, Michael J. Gidley3, Peter J.
Butterworth1 and Peter R. Ellis1* 1Biopolymers Group, Diabetes and Nutritional Sciences Division, King’s College London, Franklin-Wilkins Building, This dilution yields bulkier fecal matter a n d lower colonic pressures. This is thought to be the primary mechanism of dietary fiber in preventing diverticular disease (Findlay et aL, ; Brodribb and H u m p h r e y s, ).
The effects of this dilution on lipid metabolism involve an alteration of digestion and absorption of fats. Re-evaluation of the mechanisms of dietary fibre and implications for macronutrient bioaccessibility, digestion and postprandial metabolism - Volume Issue 5 - Myriam M.-L. Grundy, Cathrina H.
Edwards, Alan R. Mackie, Michael J. Gidley, Peter J. Butterworth, Peter R. Ellis. The particles are synthesized predominantly in the liver (and to a lesser extent in the intestine) as lipid-poor precursor particles (prebeta HDL) containing apoA-I (Figure ). 9 Nascent HDL interacts with the plasma membrane of cells, collecting lipid through an ATP-binding cassette transporter-A1 (ABCA1) mechanism.
3, 4 The cholesterol and. Dietary fiber (British spelling fibre) or roughage is the portion of plant-derived food that cannot be completely broken down by human digestive enzymes. It has two main components: Soluble fiber – which dissolves in water – is generally fermented in the colon into gases and physiologically active by-products, such as short-chain fatty acids produced in the colon by gut bacteria.
An increase in viscosity in the GI tract following soluble fibre consumption also seems to be an important mechanism linked to improvements in lipid metabolism, particularly the lowering of fasting plasma cholesterol concentrations (,).
Some or all of these improvements in lipid and carbohydrate metabolism may occur as a result. Numerous mechanisms of action have been identified which are related to the type and the physicochemical nature of the fibre.
This review concentrates mainly on the serum cholesterol-lowering effect of dietary fibre, its colonic fermentation, and finally on some possible adverse effects that one should be aware of when consuming high amounts of.
On the mode of action of lipid lowering agents, V: kinetics of the inhibition in vitro of rat acetyl-CoA carboxylase. J Biol Chem. ; – Medline Google Scholar; 39 Malmendier C, Delcroix C. Effects of fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia.
Atherosclerosis. 40 Einarsson, K, Ericsson, S, Ewerth, S, et al. () Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism. Eur J Clin Pharma Suppl.
1, S53 – S 41 Aldridge, MA & Ito, MK () Colesevelam hydrochloride: a novel bile acid-binding resin. Lipids publishes high-quality peer-reviewed papers and invited reviews in the general area of lipid research, including chemistry, biochemistry, clinical nutrition, and metabolism.
Abstract The effects of dietary supplementation with coconut oil on the biochemical and anthropometric profiles of women presenting waist circumferences (WC) >88 cm. The interaction of dietary fibers and cholesterol upon the plasma lipids and lipoproteins, sterol balance, and bowel function in human subjects.
J Clin Invest. Dec; 60 (6)– [PMC free article] Grande F, Anderson JT, Keys A. Sucrose and various carbohydrate-containing foods and serum lipids in man.
Am J Clin Nutr.